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The constant remodeling of the actin cytoskeleton into filopodia lamellipodia and stress fibers is essential for cell migration as. Mg 2 ATP-bound monomeric G-actin is incorporated into the growing filaments at the barbed end and ATP-actin is then converted into ADP-actin as actin monomers are shifted along the filaments toward the pointed end 115 116.
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